Researchers from Shanghai Jiao Tong University have made an important discovery: perfluorononanoic acid (PFNA) and perfluorooctanesulfonamide (PFOSA) — two types of so-called "forever chemicals" — may contribute to accelerated biological aging in men aged 50 to 64. This information was published in the journal Frontiers in Aging and is reported by Lenta.ru.
PFAS (per- and polyfluoroalkyl substances) got their name due to their persistence in the environment and widespread use in non-stick coatings, water-repellent fabrics, packaging, and firefighting foam. These synthetic compounds are resistant to degradation and tend to accumulate in ecosystems and the human body. Researchers have previously pointed out the association of these substances with various health risks, such as cancer, obesity, infertility, and hormonal disorders.
In the study, scientists analyzed data from 326 participants of the National Health and Nutrition Examination Survey conducted in 1999-2000. Blood samples from the subjects were tested for levels of 11 PFAS, and DNA methylation, which affects gene activity, was assessed. Using 12 different models of "epigenetic clocks," researchers were able to determine the biological age of participants and compare it with their chronological age.
It was found that 95% of participants had PFNA and PFOSA in their blood. Moreover, high concentrations of these chemicals were statistically associated with accelerated epigenetic aging only in men, while no similar association was observed in women.
Researchers suggest that middle-aged men may be particularly susceptible to external stressors, which could amplify the effects of chemical pollutants. Additional factors, such as smoking, may also influence aging levels.
Previously, the FMBA reported that the aging process in humans begins at the age of 25.
